NK Assay Full Panel |
||||
| IVIG | ||||
| dilution | 0 mg | 6.25mg/ml | 12.5 mg/ml | |
| 50:1 | 12.3 | 4.9 | 5.9 | |
| 25:1 | 7.5 | 5.5 | 5.2 | |
| 12.5:1 | 3.6 | - | - | |
| range | ||||
| CD3% | 65.5 | 60~85 | ||
| CD19% | 19.2 | 2~12 | ||
| CD56% | 14.6 | 2~12 | ||
| CD19+CD5+ | 8.8 | 5~10 | ||
| TH1/TH2 Intracellular Cytokine | ||||
| TNF-a:IL-10 | 31.3 | 13.2~30.6 | ||
| IFN-g:IL-10 | 1.7 | 5.8~20.5 | ||
The effect of IvIg is non linear. I think there is an error on the flow cytometry. Take a look at 50:1 dilution, if 6.25mg/ml IvIg is able to kill 4.9 cells, I bet 12.5mg/ml should be able to suppress even more! Sorry me! Immunologist2 said IvIg never worked in linearly. It sometimes work in paradox. Why on the 25:1 concentration, if at 6/25 mg/ml IvIg the killed cells is 5.5, why increasing the dosage to 12.5mg/ml does not have a significant suppression? It was just 5.2. I am recommended to have low dose IvIg only.
I do not believe that I need to have to undergo an immunologic treatment. My NK cell count CD56% is just above the border. Quantitatively I have the count, qualitatively it has no killing power. I thought I will be the first patient to escape LIT. If this happens, I will publish my good news on the headline of our local newspaper. Immunologist2 said I have if I have category 5 problem only, he will not suggest any LIT at all. But I have compound problem. Category1,2,4 and 5. Therefore, I need lymphocyte immunization therapy. Good alibi.
CD19% is high. But other two immunologist said it has no effect on fertility. Immunologist2 said. CD19 is antibody producing cell. No wonder I have anti-sperm antibody. It is also likely that I will produce anti-progesterone antibody.
I will have my IVF first. I don't believe much in immunology. He said my eggs will be surrounded by TNF-a... Grrr....
What can I still say? I concede! Ooopss... I forgot to ask the mechanism of Lymphocyte Immunization Therapy (LIT). Oh never mind! I will get crazy. ^.^
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