Tuesday, June 24, 2014

Karyotype - two perspective

Two perspective: OBGYNE1 vs MyFairy Godmother.
Obgyne1- reproductive endocrinologist vs My Fairy Godmother- reproductive endocrinologist (ivf specialist)

OBGYNE1 believes in the survival of the fittest. Nature has its own way of extricating abnormal chromosome. Don't worry on the 1% morphology. Abnormal sperm can't fertilize egg. Healthy motile sperm will grab the opportunity first. Chromosome study is just a waste of money.

My Fairy Godmother [ivf doctor] requested the karyotyping study. Her basis for that study is OATS, I guess. Oligoasthenoteratozooapermia (low motility, low concentration, low morphology). I am clueless on why we did not have further chromosome study afterwards. Maybe I made a wrong comment... I said I want frozen embryo transfer, I want PGS. PGS is banned in Philippines.

Back in my mind, I was thinking could the karyotype result be wrong? Why the abnormal cell of my husband is 1 out of 30 cells? Is there a mutation? Is there a difference if the abnormal cell is 2/30, 3/30... 30/30? I wished to check with another lab- but where? Question: What if the second test says: no problem, then which shall I believe? Geneticist to the rescue.

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Reading material
Chromosome Segragation Analysis [Yilmaz]
What is mosaicism?
http://ghr.nlm.nih.gov/handbook/illustrations/mosaicism

What is chromosome translocation?
http://arbl.cvmbs.colostate.edu/hbooks/genetics/medgen/chromo/translocations.html

Genetic causes for miscarriage

and there is lot of people complaining chromosome related miscarriage in forums http://community.babycenter.com/post/a24342903/four_consecutive_chromosomal_miscarriages

Aneuploidy frequencies in semen fractions from ten oligoasthenoteratozoospermic patients donating sperm from intracytoplasmic sperm injection.[Pfeffer]
- conclusion: OAT may increase risk of aneuploidy offspring.

Chromosome Segragation Analysis in Human Embryos Obtained from Couples Involving Male Carriers of Reciprocal or Robertsonian Translocation[Yilmaz]
- conclusion: Clinical pregnancy Robertsonian vs Reciprocal: 62.5% vs 19.2%

Relationship between embryo quality and aneuploidies [Baltaci] 
-Obesrvation: Many high grade embryo based on morphologic evaluation were detected to have chromosomal abnormality.


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