Saturday, January 31, 2015

My bulging tummy

I am not too imaginative but I feel my tummy had bulged a bit. My weight remains 130 pounds. I am acting like a pig these days. Eat, sleep, eat and sleep. Luckily, I dont feel that I look like a pig yet. My BMI is 21. My gynecologist had put me on house arrest. At least, my sleep has improved these days.

Bulging tummy means more space for my subcutaneus injections. ^.^ Fluid retention, sweating, hormonal imbalance and abnormal blood pressure swing is not uncommon.

Ei, what is Disuse Syndrome? Am I put under house arrest because of the risk of miscarriage or the risk of getting infection?

Relax

Whilst CRP + and DRVVT have increased, I find myself relaxed. Hehe, ignorance is bliss. I can sense that my immunologist is on panic mode. Last night, he asked me when is my next check up with my gynecologist? I told him this coming friday. He prescribed Transderm Nitro patch to dilate my blood vessels. In the middle of a certain topic he asked again when is my next consult with my gynecologist? I asked if he wants me to move my check up to an earlier schedule?

Oh, never mind. He wants another bhcg and progesterone test to check the embryo's health. Ultrasound is useless for now. I need to see him again on Wednesday. Ooops, is my name included in his vip list? What time was my last dose of Imuran? It sounds scary. Let him do the worrying. ^.^ I seat back and watch him do his craft. Relax!

Next friday's ordeal- the heart beat. Sometimes I still ask myself : am I dreaming? I cannot believe that I am becoming a mom soon. I pray for a heart beat and successful pregnancy.

Friday, January 30, 2015

5w4d

My blood pressure is 126/66. In the past, the average was 100~110/ 60~70. Could this be a sign of preeclampsia? The nurse said she prays for twins. How many do implantation do I pray for? I was speechless. I asked myself: what if I had twins? Am I expecting higher blood pressure in the next few weeks? Come what may! 

Shortly after greeting my gynecologist, I cried. I don't understand why my new gynecologist keeps on pushing me to go back to my monstrous gynecologist. Is she teasing me or she really meant it? Hehe, she was shocked to see me crying. ^.^ I hope not to hear my monstrous gynecologist name again. I have stuffy nose and headache now. I can't control my emotions.

The gestational sac is now visible. This is a singleton pregnancy. Thank god.
Gestational Sac: 0.81cm
Yolk sac: 0.33 cm

Since, a pulmonologist has ruled out that I have Koch's lesion. I am safe to take Imuran. Imuran started this afternoon. She said it is too early to have high ESR. I trust and surrender.

Thursday, January 29, 2015

Of prophecy

Should I or should I not believe in the prophecy that the end of the world is on February 5, 2015? To me, prophecy is a non sense. To see is to believe. Shhh... I still have the tendency to believe that my doctors are doing some prophecy on me.

... my immune cells may flare during pregnancy
... immune suppressants may cause cancer


... I should use minimal suppression because gynecologist believes that....
....I should use maximum suppression because immunologist believes that...

I am stuck in between. What is wrong in believing in prophecy? What will I lose if I believe? I am afraid to verify reality of these prophecy. But, who is the supreme prophet? I am confused. I wish to tell Simon2 that Simon1 asked me to take Imuran.

It maybe too late. I am still optimistic that I can surpass my first panic moments. After all, I believe other doctors don't use Imuran anyway.
 

My first panic- inflammation

I regret of my decision of postponing Imuran. I will rush to my gynecologist today. I was warn that my immune cells might flare during pregnancy. Wait! Let us see if it is true to the entire population. Let us see if it will happen to me. A decade ago while I had uveitis and arthritis, i remember my ESR never gone beyond 40. I never had systemic inflammation.

ESR -erythocyte sedimentation rate is a measure of inflammation activity. The normal value is less than 20. The presence of Crp - C reactive protein means I have a systemic inflammation. No wonder I feel slight mucle pain.

Jan 23- ESR - 23; CRP -
Jan 28- ESR - 45; CRP +

I thought my immune cells are quiet this time. I just have lymphocyte immunization therapy. I was so happy not to see any pustules. Although, I havent seen Simon. From now on, I will play the Simon Says Game. Simon says: take Imuran. Yes, Simon!

It is confusing. There are two Simons.

My progesterone had dropped

I had my 5 day blastocyst transfer on Jan 13.
Jan 21 (4w1d) E2 -11568; Hcg- 99.25;    P4-52.58
Jan 23 (4w3d)                    Hcg- 332.13;  P4- 57.94
Jan 27 (5w0d)                    Hcg- 2761.09; P4-38.8

My progesterone had dropped. Pessimism started to bug me. Few days ago, my friend had failed ivf. Our cycle was only 5 days apart. She had uterine biophysical score of 19/20. I could not believe she had an implantation failure. She had LIT and 3x ivig. I began to suspect that there was lapse on part of our immunologist. Oh no! Or perhaps, something went wrong with her th1:th2 again. Our case is very similar. But, we don't share the same ivf doctor. Or is it the lapse of her ivf doctor.

Could I be having a blighted ovum? But, we transferred two embryo. I pray for at least one implanted embryo. Let it be. I don't know if I deserve god's grace. I will cry if there is no gestational sac on saturday. (5w5d). Scary! I still have the Jayden's Coke Deprivation Syndrome within me. ^.^ I have never outgrown my emotions. What should I do next, if I have failed pregnancy?

I feel slight throbbing sometimes in my pelvic area. I hope the throbbing is not in the fallopian tube.

What is anti-progesterone antibody? Grrr... I miss my beloved immunologist.

Tuesday, January 27, 2015

Contaminated water

Oh no, I accidentally sipped a mouthful of contaminated water. I pray it will not result in diarrhea. Let us see the efficacy of my ivig. I will eat yogurt later.

Insomnia again

I sleep at 5:30am and woke up at 9 am. Sore throat! I don't know if I can survive this pregnancy.

Monday, January 26, 2015

A tale of anitphospholipid antibody from a friend

Once upon a time, I dont like my beloved immunologist. I always complain him of using a cannon ball to kill a mosquito. Everyone should check their antiphospoholipid antibody. Even my husband needs to check his antiphospholipid anybody. I made a joke to a fellow patient, I said my husband needs to have Smoflipid and heparin first before engaging in any sexual intercourse. Wahaha.

Ooops. I was surprised. Her husband has antiphospholipid antibody. The KCT score was 200 (normal is 75). Her husband had angiogram in the past but there was no significant findings. Not so recent, her husband was hospitalized again due to shortness of breath, muscle soreness and etc... He was discharged from the hospital after a week of stay again with any significant findings. Angiogram was scheduled on the succeeding week.

On the day of discharge, although he was very exhausted he still accompanied his wife to our immunologist. I salute to their determination! Midnight schedule does not shun him from pushing thru with the consult despite of his condition. Voila! Both husband and wife KCT result was there waiting for them in the clinic. Our immunologist said his husband has high risk of stroke and heart attack. Then, they shared their story to the immunologist. Shortly after the consult, his husband was confined under the care of our immunologist. He had Smoflipid and blood thinner. Case closed! No need to do the angiogram. He has blood clot in the lungs no wonder cardiologist always clear him.   I just wonder why nobody from the other hospital has the brain to solve his case. Now, his husband is perfectly well but takes an oral blood thinner. I was happy to meet them again after a long while. I pray for the success of their ivf.

Paranoid over Imuran



Infection
1.       I still get pustules on my 5th LIT. My immunologist said there must be an infection somewhere. He then asked for pap smear, urinalysis and chest xray. Upon seeing my xray, he asked if that was my xray? That film looks like a smoker’s lungs, and I claim that I am not a smoker. I have tuberculosis.
2.       I hate this report. “… right apex appear to be old lesion and insignificant”
a.       How can this be an old lesion if the 2009 xray report doesn’t have such comment?
b.      How can this be insignificant if the lesion is new? I mean if I have active tuberculosis
3.       I went to a rheumatologist because she said: “Xray was done to detect any apical lesions that may be part of ankylosing spondylitis.”  Honestly, she can’t see any lesion. She said she believes a pulmonologist may not be able to see it as well. I better go to an infectious doctor.
4.       I went to an infectious doctor. She suggested a tuberculin skin test. I withheld because I cannot go back to her in 2 days for the interpretation.  Sputum test is difficult to detect since I am not coughing. 
5.       I went back to my immunologist, I told him I had #3 and #4. I told him that I am afraid of getting a false positive from the tuberculin skin test because I always get a delayed type cytotoxic reaction from LIT. The skin test cannot differentiate active from latent tuberculosis. I am dying of smoker’s lungs already yet he never referred me to a pulmonologist. ^.^ What is the worst case scenario, if I have latent tuberculosis? Immune suppressants may give opportunistic growth to my tuberculosis bacteria. He said he can use minimum suppression + Ivig. Let him do the worrying. 
6.       I went to a pulmonologist. He said I don’t have a lesion; no smoker’s lungs. 
7.       Case closed! I just got challenged with #2. To distinguish an old from new scar. If the radiologist writes “A small calcific density and very minimal streaky densities are seen at the right apex.” I will not look for other specialist. I will take her word for it.

TNF-A inhibitor and cancer
12 years has lapse since my last check up with my rheumatologist. I told her I will be having my ivf soon. Any comment on immune suppressants? What will be my pain reliever? The last time I remembered, cox-2 was recalled. Ai, never mind…  I told her that I pray I will not need to see her. I don’t know what my immunologist will prescribe. I hope we will never need to use a TNF-a inhibitor. If I go to the websites of some tnf-a inhibitors like Embrel or Humira, there is a warning that their product may cause cancer. Yes, it is mandated by FDA that drug companies should make post market surveillance and report all cases. Even if  1/1000 patients had side effects, the consumers must be warned. I know my immunologist is very fond of Imuran. Imuran can also lowers TNF-a why its warning is it contraindicated to leukemia patients/ family history of leukemia only? Hehe... no comment ^.^  What is the most strongest immune suppressant she had used on her patient? No comment. ^.^ I need to pray over my medicine. Like for example, Methotrexate it can cause drug-induced lupus etc… but it was the only available medicine in the past. One of her patient died of gastric ulcer because he refused to take the DMARD. Ai… pregnancy is dumb I do, dumb I don’t. I have family history of cancer. It seems to me that cancer is inevitable.

My new gynecologist strongly advised me not to get pregnant on the very first day she saw me. She told me that I tell my immunologist not to use Imuran. Pls use a milder immune suppressant. She said immune suppressants may cause cancer.

Does having autoimmune disorder increase my risk of having cancer with immune suppressant?
I don’t want to think too much. I told my immunologist that I trust him on whether lowering tnf-a will cause cancer or not. I was willing to take Imuran but I remembered the tuberculosis scare.

Help, why do I need Ivig?

I had my ivig today. The resident doctor asked me why do I need Ivig? Oh no! I need to brush up my immunology. Doctor, doctor where are you? I just replied I need ivig because my immunologist said so. It is shameful, this is my third ivig, yet I dont know exactly why I need an ivig infusion.

What is ivig?. Ivig is an extract of human blood which contains antibodies to diseases. It is used for patients born with lack of antibodies blablabla. In my own opinion, my case is not in the list.

Let me make a guess. Oh ever mind, I dont want to guess. How does ivig help? If I have infection, it might help... grrr... why do I need Ivig?

How does it suppress nk cell? And how does it lower the tnf-a:il-10?

My prenatal vitamins

The other day my friend called me to sell Usana vitamins/supplements. I told her I enjoyed minimalism. This is the list of my vitamins/supplements: folic acid, calcium, methycobalamine, vit d3, vit e and vit c are included (nothing follows!). Almost all of my vitamins and antioxidants are removed. She said: Prenatal vitamins is vital for the nutrition of the embryo. Well said!

My immunologist commented that he is doing immune suppression on his patients while his partner keeps on giving multivitamins to his patients. Gluthatione, Co-Q10 and other prenatal vitamins drive him crazy. He commented these vitamins are just boosting the natural killer cells. Yeah! Great! 

He gave me phospholipid/ hepatoprotector instead.  Nevertheless, I cant keep track of my daily medicine - too many! I need to use medicine organizer as I am so forgetful.

Sunday, January 25, 2015

Imuran vs Tnf-a inhibitor

I wonder what is the difference between Imuran and Tnf-a inhibitor? Why Embrel, Humira website have a strong warning that their product can cause cancer. Why Imuran is only contraindicated to people with family history of leukemia?

My second thought on Imuran

Dont you know that there is a procrastination gene? It is a unique gene that is only be found in the genes of my husband. Since sunday is a rest day, I let him procrastinate to his heart content. I believe he must be exhausted with our last consult with my beloved immunologist.

I am slowly learning the craft of procrastination. He was watching television all day. Hey, where is my Imuran? Instead of starting the first dose of Imuran on Sunday morning, I have moved it to Sunday evening. It was 5 pm already, I guess he had his successful butt implantation on his couch. Meanwhile, I was just reading my own diary/ blog before we go to the mall for dinner. I will just buy Imuran in the mall.

Ooops... Two months ago there was a tuberculosis scare. It seems that I have a Koch's lesion. Ehem, why would I give opportunistic growth to my tuberculosis bacteria? I will postpone Imuran til my next consult with my beloved immunologist.

Thanks to the procrastination genes.

Saturday, January 24, 2015

The forbidden apple- Imuran

My gynecologist suggested immune suppression. But, she told me I can eat immune suppressants other than the forbidden apple. Her premise is lowering tnf-a may cause cancer. I tried to negotiate with my immunologist - no forbidden apple please. He is not a fan of prednisolone. He prefers Imuran over prednisolone.

Imuran is in the market for thirty years already. It is primarily used by kidney transplant patients even before the cyclosporine has come along. He told me if I go to kidney center, I can pinpoint the prednisolone users from Imuran users. Prednisolone users tend to have facial edema, etc... Imuran can help minimize the dosage of prednisolone.

I heard scary story of Imuran in the past. A patient almost died of infection because of Imuran. Plus, my gynecologist concern immune suppression may cause cancer. The forbidden apple is very attractive and it seems delicious. My resistance is futile.


http://www.drugs.com/sfx/imuran-side-effects.html

Soya and Anti-phospholipid antibody

I hate soya. I tried to skip bean curd in my diet for about three years already. I am not allergic to soy products. In fact, I have just survived the soy-based anesthesia. I suspect soy products can cause arthritis to me. Wait, do I have uric acid? I don't have uric acid. I am not considering to give soya a try! I hope it is a worthwhile try.

Anti-phospholipid antibody usually attacks the blood causing it to clot and it also attacks the placenta. Soya has a protein called phospholipid. Having soya on my diet translates to having phospholipid on my blood stream. The soya based phospholipid will compete with the binding site of the anti-phospholipid antibody. My doctor said since giving that product to his patients he never use more than one ml of heparin on his patients. Fewer gestational diabetes and preeclampsia as well.

Btw, the main component of the Smoflipid is soya. It main function is to lower nk cell and improve the antiphospholid antibody. Triglyceride and cholesterol should be checked before giving the Smoflipid. Otherwise, it may cause pancreatitis. I have a new liver supplement, Essentiale. It is soy based phospholipid! I just got lost on how the Smoflipid can lower the immune activity.

I will slowly decipher the link below.

http://www.preventmiscarriage.com/documents/Intralipid-Therapy-for-Recurrent-Pregnancy-Loss-v19.pptx

Living a vampire life

I just got home from my immunologist clinic. It is 2:43 am already. I told him that I am high on drugs. It was 1.5 hours of informative consultation. I need blood! My vampire I need donors for my upcoming LIT. I need Ivig on Monday.

Insomnia

I slept after 4 am last night. I have unplugged my clock. Checking the time makes me more irritable. I woke up at 9 am this morning. It is barely 5 hour sleep. How can I survive this pregnancy? I have minor sore throat. My white blood cells are slightly elevated.

I really suspect the culprit is Gestone. In theory, it should act like a sedative ya. Let us see if i will be mentally alert on my consultation with my immunologist later.

Thursday, January 22, 2015

I have broken the curse- next chapter begins.

First thing in the morning, I braved myself to test my urine on my cursed home pregnancy kit. It has been with me for 22 months already. It is 22 months since we seriously trying to conceive. I tested positive in my cursed hpt. Today, I am happy to announce that I have broken the curse. Beta hcg result will be out this afternoon.

I was told my gynecologist that I need to see my immunologist as soon as possible. I need immune suppression. Otherwise, my ankylosing spondylitis may relapse. It sounds like there is more challenging obstacles ahead. I went to two laboratories one for blood chemistry and  the other one immunology. Scary and costly.

Chapter one of my diary is officially closed. Sheila got positive in the home pregnancy kit. The next chapter begins.

I had accupuncture today

I am not a fan of alternative medicine. I complain alternative medicine is slow acting. I am currently suffering from insomnia, indigestion, flatulence, slight hyperacidity and constipation. If I am going to take western medicine, I guess I will be given Valium or other muscle relaxant, dyspepsia medicine, Disflatyl, Misoprostol and what.. I guess I will end up adding few more tablets to my tummy bank.Will there will drug interaction between Valium and my other medicines? Are they pregnancy safe medicine?

I refuse taking more medicines. I feel it is forming a cocktail in my tummy already. I will rely on drug free alternative medicine for now. Let us see if I will still say accupunture is a placebo thing. Whether it is a placebo or not, I hope it will boost my morale and well being.

Btw, I saw many baby pictures in the accupunture clinic. I just dont know if the patients completely rely on accupunture or they combine western and alternative medicines for their infertility treatment.

Wednesday, January 21, 2015

Cycle day 30- My friend is pregnant

My fellow patient (same immunologist) recently had confirmed a fetal heart beat. It is amazing. After the immunologic treatment, she had her bingo thru iui! Despite of her recurring endometriosis, despite of his husband's antisperm antibody and motility, she did it. She had big mass and had her laparoscopy about a year ago. Endometriosis is more challenging than my case.

What is wrong with us? I guess because I am terriby old! I hope my suspect dna fragmentation is just afiction. Will our ivf be successful? Blood test tomorrow for the true bhcg. I am expecting a 200 level.

Insomnia

What causes my insomnia? I remember I started complaining my difficulty to fall asleep after the embryo transfer. I really suspect the Gestone.

I just wonder why some people complain Gestone for insomnia while some people complains Gestone cause sleepiness? Maybe I need to inject Gestone earlier than 9 pm. I will gradually move its schedule into the morning.

Btw, what should be my ideal progesterone level? My V is like a coin bank nowadays. One Utrogestan 200mg in the morning and one at night.

http://www.drugs.com/sfx/gestone-side-effects.html

Dont count your chicken before they hatch

My friend told me that the her doctor said hcg will be flushed out by the body within 4 days. Why wait longer? She told me she can do bhcg on a certain day already. I had an exciting day today. I had my hpt and bhcg. After all test was done, I asked the nurse when should I do my bhcg? She said I need to wait two days more.

Oh no, I may have false positive result. But, I have shared my good news to my husband. I dont want to lead him to frustration. My bhcg is 99.25. What will happen in the next few days?

Finally, I told my husband regarding my false news. He said dont count my chicken before they hatch. Oh yeah. His sister-in-law has just had an abortion because no heart beat. His colleague has a cord coil accident before. And, he reminded me of my cousin-in-law who had a cord coil accident also. Ai! That is wisdom. Counting will led me into frustration.

Dont count the hatching grade embryo unless you see the baby!

Tuesday, January 20, 2015

Cycle day 29

I was tempted to use my sister-in-law's hpt kit. Should I test it now or should I postpone it to Friday? I may get a false positive because of Pregnyl. Whatever... I had my urine test. After a minute it was still one line. I had my breakfast. I kept this as a secret to my husband. How could this be? Why am I so unlucky with the hpt?

After the breakfast, I checked the hpt kit again. Oops, there was an additional faint line. Wa! I am satisfied. For the first time, hpt kit seems working. My sister-in-law's kit is indeed lucky! Ei, what is next? I will have beta hcg now or wait til friday? I am excited. I guess this is it!

My beta hcg value came out 99.25. My estradiol had shoot up to 11568. Oh no! The nurse just replied it is safe for me to have bhcg on friday. False positive perhaps. Whatever, as long as there is no menstruation yet, there is still hope. Hold on Shel, dont cry in the next few days.

http://www.babymed.com/hcg-level-in-early-pregnancy

I am still wide awake again

I was sleepless last night. I cant sleep. I blame Gestone is causing me sleepless. I blame prenisone causing me indigestion. What medicine to blame for flatulence?

I drink soda water for the burp. I put hot packs for the fart. I still cant fall asleep. I will turn my ipad off.

My husband's sister-in-law just had an abortion

All siblings from our family are fertile. I am the only expection. It seems like a challenge on my husband's side to have nephew and niece. The youngest brother had one daughter. I guess the daughter is about 8 years old already, nothing followed. Does one child policy exist in New Zealand? Work related stress? Nobody to take care of their daughter? Are they ligated? Or they weren't successful on their succeeding tries?

The younger brother was married 5 years earlier than us. They were infertile for many years. They had just announced their natural pregnancy on Christmas day. They were happy to show us the embryonic sac. Nice timing, I thought that was an answered prayer. Unfortunately, they just broke a sad news. They needed to do an abortion because there was no heart beat. I would like to recommend them to have genetic study on the embryo. Shhhh.... They reside in Singapore this also means our relationship is not close.

I guess lightning will not strike the same place twice. My husband's sister-in-law can't have autoimmune problem as well, unless my father-in-law is the unluckiest person on this planet.

I can't help but to suspect genetics. Maybe DNA fragmentation runs in their family. Oh my god, how many percent drop is my confidence level? I really feel emptiness after the embryos were transfered. I really need the best of luck!

Whatever... I need an implantation first to prove my reproductive system is functional. In the event of no heart beat, I need to check my immune profile. Then, I shall suspect my husband's DNA. Omitofo!

Monday, January 19, 2015

Will I cry if implantation failed?

Have you heard of JCDS- Jayden's Coke Deprivarion Syndrome? Its symptoms include crying and screaming. Oh my naughty nephew, Jayden! Am I also having a JCDS?

I cried after my 4th and 5th iui failure because I feel deprived and helpless. Why is conceiving is a very easy task for other people? We are the dumbest couple on this planet! Then, I told myself I will not cry anymore. But, ivf is my second line of offense. This equates to game over if it fails. I don't know whether I can control my emotions.

Actually, I have 75% confidence that my embryos will implant based on my uterine profile score. But, when the embryos were put in, I began to feel emptiness. It is now a battle between optimism and reality. I feel like playing two- coin tossing game. Although, I have 75% chance of getting at least one head based on probability. The reality is once those two coins were tossed, it is beyond my control. I cant control implantation either. I wanted to win this game badly. Yeah! I dont recall seeing enraged people playing in casino.

Relax! Implantation is just a like a game of chance. I will act as if those chips meant nothing to me. I will act as if Ivig, lymphocyte immunization therapy and money means nothing to me. I surrender to my fate. I accept life is like a board game. Everyone has equal chance. People who tend to emerge as winners are just born lucky. Unfortunately, I am not born lucky. I learn to accept this hard fact. I am still trying my best to reach the finish line of my Snake and Ladder game. I hope I am more emotionally matured by now. No more JCDS!


the hospital was absolved

 I am afraid of blood. I told my doctor that I will be getting blood from the blood bank. He refused. It is really difficult to convince people to donate blood.

Grr... this new is really heart breaking. The donor has passed the HIV screening test during his HIV incubation period. Therefore, the hospital was absolved from the HIV contamination issue.

If confirmed positive pregnancy, I need another round of lymphocyte immunization therapy. Blood, again!

女童输血染艾滋 医院无过错




新京报 01-20 03:32  
                                        
被感染了艾滋病病毒的毛毛
近期,福建一名5岁女童毛毛(化名)因输血感染艾滋病事件,引起社会广泛关注。据该省卫计委调查,毛毛因在手术过程中输注“窗口期”血液而感染艾滋病病毒的可能性极大。以目前的科技水平,这种风险不可避免。据新华社

■ 调查

献血者不知自己感染艾滋

2010年,刚出生8个月的毛毛在福建医大附属协和医院接受先天性心脏病手术治疗。手术以后,一直发烧。2014年,再次到协和医院治疗,检查发现艾滋病病毒(HIV)抗体阳性,后确诊为艾滋病。
事后,福建省卫计委组织专家调查,认为供血的福建省血液中心和实施手术的福建医大附属协和医院都不存在违法违规行为。
福建省卫计委医政处处长杨闽红说,患儿在手术治疗期间,曾先后输注过8位献血者的血液。经查,确认其中一位陈姓献血者目前检测HIV抗体为阳性。该献血者曾于2010年3月无偿献血,当时血液检测结果合格,此后未再献血,在本次调查前并不知晓自己已感染HIV。
综合考虑患儿父母HIV抗体检查阴性的结果,调查组专家认为,毛毛因输注“窗口期”血液而感染HIV的可能性极大。
“‘窗口期’是指人体感染艾滋病病毒后,需要经过一段时间后血液中才会产生艾滋病病毒抗体,在此期间HIV抗体检测呈阴性。”杨闽红说,“窗口期”就是感染病毒后到能被检测出来之间的时间窗。“窗口期”是人类所有输血治疗依靠现有的检验手段无法规避的风险。“多数人在感染艾滋病病毒后有2至4周的‘窗口期’,‘窗口期’感染的概率大约为五十万分之一。”杨闽红说。

■ 回应

卫计委:将给人道救助补偿

杨闽红说,根据《侵权责任法》和《医疗事故处理条例》,对输注“窗口期”血液引起的HIV感染,血站和医疗机构并不存在过错。
福建省血液中心副主任赖东生说,由于“窗口期”无法避免,但又必须输血,所以只能呼吁捐献更多的安全血液,献血者应具有健康的生活方式。
福建省卫计委表示,将给予患儿人道主义救助补偿。
患儿方的代理律师吴武萍认为,如果确实排除医疗卫生机构的责任,而是“窗口期”感染,则应该由相关部门按照公平原则承担责任。“对毛毛这类病人理应建立‘无过错伤害’的补偿机制,而非‘人道主义’救助补偿。这样才能共同解决‘窗口期’感染群体的问题。”吴武萍说。
据不完全统计,中国有78万艾滋病病毒感染者,其中经医疗输血(包括使用血液制品)以及商业采供血感染艾滋病病毒的人数约为6万余人。据福建省卫计委透露,HIV抗体为阳性的陈姓献血者的血液还输注给其他两名患者,目前卫生部门正在追踪调查。因举证困难,难以确定医疗机构的过错责任,很多因为输血感染艾滋病病毒的人面临困境。
除艾滋病,据专家介绍,包括乙肝、丙肝、梅毒等都有“窗口期”。长期以来,对这些“窗口期”输血感染群体的补偿,尚未有明确政策。

I am still wide awake

I woke up at 3:30 am. I had a bad dream. Why did I import scratch paper? When I woke up I begin to think on how to dispatch our dead inventory. My work and life are integrated. How to separate work from private life?

Yay! What is my stress level now? I cant still sleep. It is 6:20 am already. Can sleeplessness have effect on the implantation? Can it boost my NK cells?

Concentrate! Sleep! I have an inverted triangular wrinkles while trying to frown my way to sleep. Hey! Today is day 28- tuesday. Three more sleeps to go, then it is beta hcg day. I am tempted to try the 'lucky' hpt from my sister-in-law.

My naive questions: about bed rest

My naive questions:
1. How big is the embryo? 120~150 microns... Just guessing... Bottomline microscopic.
2. How big is the opening of my cervix? Is it open or closed? For sure, it must be bigger than the embryo size. Big enough to be seen by a naked eye.
3. Less than 30 minutes after the embryo transfer, I stood up to pee. My big question is why it won't drop?
4. I walked to the taxi stand, what ought to drop must have dropped! Am I insanely having bed rest while the embryo was flush in the toilet already?

Hay! If my naive questions were true, then the new standard for embryo transfer entails one week hospital stay. Every clinic / hospital wants to maintain their high success rate. Since, it is not implemented, ergo, bed rest is not necessary.

I will have my bed rest just to free myself from guilt. Because, I don't want to be labelled as stubborn. Hmm... I have walked few corners because I was craving for dessert last week. Sad to say, my husband cannot imagine what dessert am I craving for. Shhh... Neither do I! Finally, it was mango puree with yougurt. I lost my food craving this week. Ouch! No more pregnancy hormones? Scary.

Can I tell my reproductive immunologist that my food craving is more reliable than his beta hcg request? No kidding, I have food craving whenever I had hcg shots.

I feel bloated this cycle but I still crave for comfort food. I dont care if this is coincidence or psychologic issue. This is my observation as an iui veteran!

cycle day 27

My sister was very happy when she saw me last Saturday. It seems like all her stress was vanished instantly. Her reliever is here. She called me last night regarding work schedule. I tried to explain our investment on this ivf cycle . Sorry just be patient for a while! i am not going to office.

Today , Pope Francis is flying out Manila. Many roads were closed. My brother called me this morning asking me to open our store.  Whatever, I will be selfish for a week. Sorry guys! I know your are very busy while I am just busily playing 2048.  Please bear with me.

I don't care much is bed rest is proven efficient or not? I just dont want to regret with my actions.
How to survive the ten day wait? I have not mastered the craft of 2048. Me and my pathetic strategy yields muscle soreness. What to do? I will be staying at home til Friday.

What happened to my 'Embryo of the Year' awardee? Btw, any food to avoid? I am 100% sure that coffee not in the list.

Sunday, January 18, 2015

hpt- home pregnacy kit

My sister-in-law offered me her extra home pregnancy kit. I told her that I never get lucky with any hpt. It seems that my hpt is cursed. That product is driving me crazy. My menstruation always arrive after the hpt urine testing.

She said there is an element of luck in her hpt. Whenever she tried, she always get positive.
Hmm... Let me try on that one! How long is the half life of Pregnyl?  Why should I wait for 11 days? Should I also test the e2 and p4 together with the beta hcg? grrr... why was the nurse so inefficient?

http://www.babyhopes.com/articles/hcgshot.html

Friday, January 16, 2015

Cycle day 25- I need a miracle

Today is cycle day 25. (4 days prior to day5 blastocyst transfer) I was awaken by the ding ding ding sound. What was that? Husband, wake up! The fire alarm has been activated. I had some adrenalin rush. Husband, don't fall to sleep again. We may need to evacuate in no time. It was 3:45 o'clock in the morning.

I confirmed the ding ding sound was indeed a fire alarm. The hotel personnel said maybe someone had smoked in the room. Maybe? I cannot accept the MAYBE! Did they check the alarm source already? After calming down a bit, I fell asleep again afterwards. Luckily, no more ding ding ding sound again.

I obeyed with the nurse advice- no strenous activities after the embryo transfer. I guess the magnitude of this adrenalin rush is nothing compared to work related stress. I hope my embryos did not drop. I have been feeling menstruation sensation with little cramping. I am paranoid to check the color of my vaginal discharge. Luckily, It is still sky blue. What is the color of my urine?

I just had a roller coaster ride from Hong Kong to Manila. We passed many areas of turbulence. In fact, no hot drinks were served throughout our flight.

I believe I have did all the necessary treatment. Now, I surrender. I needed a miracle.

cycle day 24

Surrender! Good luck and god bless.

Thursday, January 15, 2015

My game is not yet over, fight!

Tic, tac, tic, tac... Today is cycle day 23. I had 24 day cycle last October and November. My agony will be over by tomorrow. Oops... Think positive! My menstruation will not come tomorrow. My period may reach 28 days this cycle.  I will have the opportunity to take the nerve breaking pregnancy test. I have no luck on this area!

I had Day 5 blastocyst transfer two days ago. The timing sounds great. Do I have a luteal phase defect? I had not discussed my concerns with the ivf doctor. I was given an HCG shot shortly after the embryo transfer. I believe this should fool my system to go into pregnancy mode. I had Progesterone intramuscular injections and pessary also. My menstrual period will be extended for a little while.

Relax! Don't think to much. I went to the clinic to have my estradiol and progesterone blood test this morning. No news is good news. What if the nurse overlooked my blood test? I am not proud to admit that I am a very impatient person. My impatience led me to call the nurse this afternoon. Hello, what? I need another injection? Is my blood test very ugly? She said it is not very ugly- dont worry. I had my Pregnyl shot again. I need to put 4mg twice a day of Estofem as pessary. Yeah! Not ugly!

As long as my menstruation has not yet arrived-  my game is not yet over. Fight! I had three injections everyday (2 heparin + 1 progesterone). I am not afraid my v is like a coin bank: 1 viagra+4 estrofem+ 4 utrogestan= 9. then, multiply by 7 days? How much is my coin bank interest? Hope there will be! I will have my pregnancy test 7 days from now.
http://natural-fertility-info.com/luteal-phase-defect.html

Wednesday, January 14, 2015

Day1 after 5 day blastocyst transfer

Today is cycle day 22. Try to name all the side effects of Gestone, Prednisolone and whatelse...
I had indigestion, light headedness and mild headache. I also feel like my menstruation is coming. I sometimes feel minor cramps in the uterus (or ovary area). Oh, perhaps that is from Viagra. 

I felt a bit guilty. I have the instruction from the Ivf doctor that I need to increase my prednisone to 25 mg after the embryo transfer. I did not even bother to break the 25 mg Predinosone into half and take it in the afternoon. I just increased the dose to 25mg the next day. Because, I have already taken a 10mg in the morning. I have a limited intelligence. Now, I am blogging to free my guilt.

15mg of prednisone will not make a big difference, I guess. Usually, prednisone is taken as one single dose, correct?

I was sleepless. I hope this was not a result of my immune armies fighting off my embryo.  Hey, I have alloimmunity to my husband's HLA already. Hihi, I am just justifying I stupidity over the missed 15mg dose. I had IVIG also. 15 mg should not create a negative result in the implantation. Fingers crossed.



Monday, January 12, 2015

Embryo transfer done- bed rest or not?

We transfer 1x hatching AA and 1x expanded AB. No more assisted hatching on the expanded AB embryo. Whatever! His target is one implantation. I want to be free from guilt! I just let him decide.

What is next? Bed rest or free to move around? What is the definition of bed rest anyway? Lay down on bed for 24 hours x 8 days = 192 hours or lay down whenever I want.

The nurse told me I am free to move around. But, the Taiwan Ivf doctor has given me an ivf schedule in the past. It says bed rest. Fly back to Philippines day 5 post transfer. I feel some of my friends are over doing it. Pee on diaper. Actually, I was somewhat convince to follow suit. I am afraid to get the diaper rash. I brought a bed pan with me. Nothing to lose, if I overdo it. For me, this is investment vs sacrifice issue.

Personally, I am not convinced that bed rest is a neccessity. But, I don't want to feel guilty of my stubborness. I had full bladder prior to the embryo transfer. I cannot hold it any longer. As the call of nature dictates, I stood up in less than 30 minutes after the embryo transfer. I have to go to the clinic on Thursday anyway. My bed pan is now useless.

I will just maximize laying down on my hotel bed. Ching, ching, ching. Are there slot machines in the hotel room? ^.^ My next question: how to beat boredom?

https://www.fertilityneighborhood.com/content/in_the_news/archive_1109.aspx
http://www.ivf1.com/ivf-success-and-bedrest/
http://www.ivf-infertility.com/phpBB3/viewtopic.php?f=2&t=24834
http://www.medhelp.org/posts/Fertility---Infertility---IVF/Bedrest-after-transfer/show/1082070

1.5 hour to go before embryo transfer

1.5 hours to go before the embryo transfer. I am stucked in the hotel blogging and counting my white hair. My white hair had an exponential growth. Is this the sign of wisdom? Is this a sign of old age or old eggs? At least, we have preserved 7 frozen embryos.

I receive negative energy from the office.  Some problems arised from the incoming shipment. Ai... I don't want to receive from calls from the supplier. I feel stress.

This led me to blogging.

Frozen egg vs frozen embryo


The other day, I saw in the newspaper that only 20 babies were born from frozen eggs so far in UK. Oopsss... With this statistics on hand, why do some Silicon Valley companies offer egg freezing? Is this part of employee retention or selling false hopes? Whatever... It is not my business anyway. This made me do some reading on frozen egg vs frozen embryo.

http://www.fertilityproregistry.com/article/lab-techniques/embryo-freezing/embryo-freezing-vs-egg-freezing
https://www.eggfreezingcosts.com/blog/difference-freezing-eggs-embryos
http://frozendonoreggs.com/frozen-embryo-donation/
http://www.fertilityproregistry.com/article/lab-techniques/embryo-freezing/embryo-freezing-vs-egg-freezing

http://www.hfea.gov.uk/46.html

I dont want to compare fresh vs frozen embryo for now.

Please pick two embryos

My immunologist says not more than three embryo. The ivf doctor asked me again how my embryo shall he put? I asked him to decide for me. He said two. His target is one fetus. Next question: which embryo? I told him again, he decide. He chose 1x hatching AA and 1x Expanding AB.

If he puts in1x hatching AA and 1x expanded AA, it may result in twins. But, may also result into triplets. If he puts in 1x hatching AA and 1x expanded AB, Hmmm, AB may also implant. It may also result in twins or triplets. AB is not the acronym of abnormal baby. AB embryo may result in cute and intelligent baby as well.


Upon reching the hotel, I was thinking that I should put 1xhatching AA and 1x expanded AA. Why not choose 1xhatching AA and 1x expanded AA for a better chance of success? It is a like a one time big time betting in casino.

What is the proverb saying dont put all your eggs into one basket?  Split my casino betting? Be satisfied with small winnings? At least, if I fail the first bet I still have chips left? At least if my 1x hatching AA and 1x expanded AB fails, I still have my 2x Expanded AA. His betting style sounds like king and queen can travel together on a same plane.  But a king and (successor) prince should not travel on a same plane. 

I wish a singleton because I have immune problem. If I wish a set of twins for my one time big time pregnancy, I may be rewarded but it entails high risks. In the end, I am indecisive. My betting style is one time big time! I ask guidance from the expert. I let him decide what he thinks is best for me.


 D5: 24/12/2014
1xHatching AA, 2xExpanded AA, 2xExpanded AB, 1xExpanding AB, 1xExpanded BC, 2xExpanding CC, 2xMorula (FC), 1xArrest
From 0PN: 1xExpanding BC, 1xHatching AA

7 Embryos frozen in 6 straws (1-1-1-1-1-2) on D5

FYI: On Day 3, Grade 2 means the embryo on average has a good quality, Grade 2- means the quality is fair. i.e. 4c2 means a 4 cell embryo with good quality.
On day 5, Grade A means good quality and Grade B means fair, Grade C means poor quality.

My embryo report

The followings are the day-to-day growth of your embryos:

D0: 19/12/2014
Egg collected: 20 (17MII(did ICSI), 1Empty Zona, 2 Abnormal)

D1: 20/12/2014
12 x 2PN, 3 x 0PN, 2 x 0PN (2PB)

D2:21/12/2014
9 x 4c2, 2 x 4c2 (from 0PN, 2PB), 1 x 5c2, 1 x 4c2-, 1 x 5c2-

D3:22/12/2014
2 x 8c2, 2 x Compact, 3 x 7c2, 1 x 8c2-, 1 x 12c2, 1 x >12c2, 1 x 14c2,
From 0PN, 1 x 8c2, 1 x 12c2

D5: 24/12/2014
1xHatching AA, 2xExpanded AA, 2xExpanded AB, 1xExpanding AB, 1xExpanded BC, 2xExpanding CC, 2xMorula (FC), 1xArrest
From 0PN: 1xExpanding BC, 1xHatching AA

7 Embryos frozen in 6 straws (1-1-1-1-1-2) on D5

FYI: On Day 3, Grade 2 means the embryo on average has a good quality, Grade 2- means the quality is fair. i.e. 4c2 means a 4 cell embryo with good quality.
On day 5, Grade A means good quality and Grade B means fair, Grade C means poor quality.


http://www.genderdreaming.com/high-tech/dream-member-access/embryo-outcomes/

Saturday, January 10, 2015

I am afraid of blood- LIT and ivig again?

After I get positive in the pregnancy test, I need another round of Ivig and lymphocyte immunization therapy. Yay! Blood products. I learned this sad news from QQ. A five year old girl from Fujian, China was infected with HIV after the blood transfusion. The family is suing the hospital however the damage is irreversible. The hospital argues the donor passed the HIV screening test. It was in the window period for incubation. Ouch! I am afraid of blood.
5岁女童因输血感染艾滋病



央视 01-11 08:31 
                                        
  被感染了艾滋病病毒的毛毛
日前,央视新闻关注了福州一名五岁女童毛毛,疑似因在医院输血感染艾滋病病毒的事件。昨天(10日),福建省卫计委通报了事件最终调查结果:一名曾给毛毛献血的献血者HIV抗体检测现为阳性。

献血者HIV抗体检测现为阳性

福建省卫计委表示,毛毛当年先后输入过8位献血者的血液,其中一位之前确认HIV抗体为阴性的献血者,在本次调查中HIV抗体检测为阳性。在对当年福建医科大学附属协和医院对毛毛进行的输血治疗,以及福建省血液中心的采血、检测、制备过程的调查中,调查组均未发现违规行为。

因输入“窗口期”血液感染的可能性极大

综合调查结果,并结合毛毛父母HIV抗体检查的阴性结果,调查组专家认为毛毛因输入“窗口期”血液感染HIV的可能性极大。经“窗口期”血液途径感染HIV属于临床小概率事件,相关数据显示感染概率大约为五十万分之一。

献血者不知情 血还输给了2人

2010年5月4日,毛毛8个月大的时候,在福建省医科大学附属协和医院做心脏病手术,手术时输注了血小板、悬浮红细胞和血浆,涉及8位献血者。福建省卫计委医政处处长杨闽红介绍说,“毛毛事件”调查重点放在8位献血者目前的病原学检测排查上。
调查组通过追踪8位献血者的相关情况,经福建省疾病预防控制中心检测排查,最终确认原HIV抗体检测阴性的陈姓献血者,本次检测HIV抗体为阳性。该陈姓献血者曾于2010年3月31日参加无偿献血,当时血液检测结果合格。此后该陈姓献血者未再有过献血,在本次调查前并不知晓自身已感染了HIV。
杨闽红还透露,被检测出艾滋病的陈姓献血者,当时献血的血液除输注给毛毛外,还输注给其他2个人。但杨闽红并没有正面回答现在另外2个输注“窗口期”血液者的情况。

毛毛代理律师:对调查结果存质疑

毛毛代理律师吴武萍表示:“我们要求他们提供当年所有的程序性文件,包括从抽血到输血整个过程,相关医务人员和工作人员是否具备资质,这样才能证明他们的整个行为是没有过错的。”对于毛毛一家的代理律师所提的要求,杨闽红表示可以沟通协调。
同时卫计委还表示,已责成定点医院和疾病预防控制中心,做好患儿的医疗救治、救助工作。同时根据《中华人民共和国侵权责任法》和《医疗事故处理条例》,要求福建省血液中心、福建医科大学附属协和医院对患儿给予人道主义的救助补偿。

可否对窗口期感染人群设救助机制?

只有五岁的毛毛,在未来很长的时间里还将遭受病痛的折磨,一次输血给一家人带来的噩运已经无法改变。希望福建协和医院和福建省血液中心的救助补偿能尽快到位,给毛毛一家带来些许的帮助。既然目前的检测手段还不能完全避免窗口期感染病毒,那么相关部门是否可以考虑建立一个救助机制,例如设立相关的救助基金,专门用于像毛毛一样因窗口期输血感染病毒的人群,让他们在遭遇不幸时能得到相应的帮助。

Auspicious day for embryo transfer

What is the most auspicious day for embryo transfer? Chinese lunar calendar, yoohoo! I dont like Jan 12 because that day is not lucky for people born in the year of the horse. My husband is born in the year of the horse. Hmmm... How can I tell my crazy ideaology to my ivf doctor? Luckily, I was able to delay the trigger by one day. Because he replied my email late. Our embryo transfer is set on Jan 13. I don't understand why 13 is considered as unlucky. Our apartment doesn't have 13th floor. Friday the 13th is bad.

I feel 13 is good. Two bumps on the number three. That, means I will have my twins. Please ride on my my crazy prophecy. It will help alleviate my mood and success chance.

I feel relaxed

I had a three hour consultation with my immunologist last Thursday. I am not alone rejecting Neupogen. RICA says leave the worrying to him about implantation failure. I feel a great relief. RICA is my mountain! Really no more worries!
I need to pack up for my flight tomorrow. Bye for now.

Friday, January 9, 2015

my theory: why Is APAS more prevalent nowadays?

I always complained about headache when I was in grade school. What was the cause of that headache anyway? I remembered That I always take Dilantin, anti-eplyteptic drug for headache. Did i have migraine attacks before? One thing for sure, I did not have epilepsy or seizure. It is water under the bridge. I just realized its side effects- grrr... I hate my pedriatrician. Oops, is there age limit for pediatrician's patient? I was not a baby then.  Age group: 7~10 belongs to them?

By the way, what are the side effects of Dilantin? Did I read it correctly- Antiphospholipid antibody, lymph node enlargement, lymphoma and etc...? I was tortured by this drug also. This drug may cause dizziness amd drowsiness. I doubted that my intellect that time was able to distinguish dizziness from headache. I guess it took the maximum dose of Dilantin until my system get used to that medicine. When I have a baby, I will make sure that we go to a topnotch pediatrics.

I hate being a naive child who believed medicines always work like magic. I was a victim of my illiteracy, I should read the the drug literature. But, I can bearly how to write A-B-C then. Sad to say, the damage is irreversible. I believe this is the cause of my APAS.

In the past, I detest immunologists I feel they do 'unnecessary' LIT for fun.  Three out of three asked me to have LIT. I feel APAS is just a fad. In my mother's generation it was non-existent or never diagnosed. I refused to join the APAS bandwagon. I just realized that APAS is a reality. It is a product of unscrupulous prescription medicine.

What about vitamin k? Nevermind...

http://www.mayoclinic.org/diseases-conditions/antiphospholipid-syndrome/basics/causes/con-20028805

http://www.inchem.org/documents/iarc/vol66/phenytoin.html

http://www.medicinenet.com/antiphospholipid_syndrome/article.htm

where is my egg and embryo report

My prediction was indeed correct. My immunologist will scrutinze the records. I told him I took the embryologist word for it- outstanding quality embryo. Period! But, what was the grade?

I will be more pressured when I see AAAAA yet no implantation. Let him do the worrying.

Thursday, January 8, 2015

Anxiety calmed

Job well done. I am lucky. I was accomodated to the thursday consultation schedule.
- immunologist consult done
- ivig later
- plane ticket booked (oh my god, 150 usd fare difference in just one day)

Anxiety calmed but I still cant sleep well. My stress hormones are now at 1 million level. ^.^ help! Ouch. I forgot to book our hotel. Anyway, tomorrow is just saturday. My flight is on Sunday!

I was a victim again. If I go to Hong kong without seeing my reproductive immunologist, then I might be offending him. I did not book my air ticket and he advises me not to go to Hong Kong yet, then I will be wasting my air fare. If he cancels my consultation appointment, then I will be in deadlock. I need to go to HK on friday for the ivig. What if, he approves me to go to Hong kong after our saturday consultation, but there is no available airplane seat?

i recruited RICA to my anti Neupogen camp

Finally, I found a new recruit willing to join my anti Neupogen camp. We will invite you to our inaguration soon.

Wow! I told him GCSF- receptor is found in trophoblast cells. I also told him that my hematologist advised me to use GCSF to stimulate the growth of my trophoblast. And I handed him a print out of my Neupogen inquiry. He then asked whether I took Neupogen or not? He silently stared at me as he waited for my answer. I said no! I did not. But I should take 300 micrograms three times prior to/ after the embryo transfer.

By the way, the print out says: Yes, gcsf receptor is found in cancer cells participularly in leukemia. Even if I have family history of cancer- that drug is safe on me.

He then asked why I don't like to take Neupogen. It appears to me that the hematologist just labelled me as a safe patient without even bothering to know the type of cancer runs in our family. What if the cancer history that I was referring to is leukemia? I may have a mutated gene responsible for leukemia. The mutated receptor may cause cancer.

Then, he told me don't take that drug. Bad Sheila played a devil's advocate again! I told him GCSF is an immune modulator. He said he knows that. There is also GCSF receptors in the immune cells. This can also cause negative reaction towards GCSF.

He needs more clinical data. So, do I. I am not volunteering to be a guinea pig yet. Now, I rest my case. I finally succeeded to recruit one LOYAL member to my camp!

Oops, He said RICA is the first clinic that was accredited by Dr. Alan Beer in Asia. Who the heck is RICA? Wahaha... I just notice the Rica he was saying is his clinic. Reproductive Immunology Center Asia!

Oops, I also saw in the web that gcsf receptors are also found in non hematopoietic malignant cells.
http://www.nejm.org/doi/full/10.1056/NEJM199012133232418
http://onlinelibrary.wiley.com/doi/10.1002/cam4.239/full

My Viagra blooper

My IQ is less than 100%. Oh my god, I took it orally. Whose fault is it? My fault or my doctor's fault? He did not even write Viagra pessary in the prescription. he said there is no such thing as viagra pessary in the market. There is only one standard form of viagra. Hehe, perhaps I was sleepy again during the consult.

I forgot how did he discover that I took Viagra orally. Ah, he asked enumerate all the side effects from Viagra and ivig. Maybe I enumerated too much. Blurred vision, palpitation etc... Good detective!

Tuesday, January 6, 2015

Anyone interested to bet on my FET outcome?

Minimum bet $50. Betting start now, closing 7am Jan 13 (before the embryo transfer). Honestly, the patient is unwilling to bet her hard earned 50 dollars on herself.

Pro:
- outstanding quality embryo (It is the embryo of the year for that ivf center. I felt like my embryos have won the 'embryo pagent'. This is true or just a consolatory remarks, I take their word for it.)
- body mass index 21.3
- lining 0.97 mm, follicle 19.3 mm a day before the HCG trigger. (Good lining)
- progesterone before the trigger 0.45; estradiol 600
- endometrial receptivity: 16 points- 60%;  with heparin it may reach to 17 point or perhaps 19 points which translates to 77% chance of conception.

Con:
- immunologic failure: cat1,2,4,5
- ankylosing spondylitis and uveitis ( autoimmune disorder)

These are my concerns:
- 20 eggs retrieved; 12 fertilized; 9 survived til day 3; 5 survived til day 5. How many will survive the freezing? It seems like my embryo had sluggish growth. But 5 had made it. My immunologist remarks keep on reverberating in my mind. Once upon a time, he told me if I won't correct my immune problem. My eggs will be surrounded by tnf-a. At the time of harvest, they may look perfect. However, the embryos will have sluggish growth. I had ivig on day 1 of the stimulation cycle.  His tnf-a theory maybe a scary truth.

- my husband's chromosome problem?
- my age? I am 38 yrs old already.
- cant understand why my embryo developed is just 25~35%. (Is it 5 or 7 embryo? )

Medications:
- ivig before embryo transfer
- prednisolone
- clexane
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- neupogen? Yes or no? Grrr...

I feel stressful and pessimistic because I am resisting the Neupogen. Relax, just believe in what I believe!

The omnipotent Neupogen

http://www.jimmunol.org/content/168/4/2011.full.pdf
http://www.bloodjournal.org/content/bloodjournal/102/2/734.full.pdf?sso-checked=1
https://kops.uni-konstanz.de/bitstream/handle/123456789/7891/Aulock.pdf?sequence=1&isAllowed=y

Should I reject or accept Neupogen?  It is an immune modulator. It suppress Tnf-a and other interleukins. It has anti-inflammatory effect. Good for arthritis as well. Neupogen can be used to fight off infection as well. Cancer patients use this drug to stimulate neutrophils to fight of infection. It can be useful to patients fighting graft versus host disease, and many more. It sounds like gcsf is a wonder drug. I just wonder why it was not used on Ebola patients?

Neupogen is also a trophoblast growth factor. It is used for patients who failed implantation with ivig and Lit.

Anyone still joining my anti-neupogen camp? Neupogen cost a fraction of ivf only. It is cheaper than Ivig. To me, It is like buying an assurance. For the meantine, I cannot accept the terms and conditions of that assurance. I don't feel its benefits outweighs the risk yet. No, for now!

In the future when I am in desperate mode, I may sign and accept the terms and conditions even without reading them. I just hope I am not yet menopausal be then.

Welcome 2015- my bumpy year?

I bumped my car today. Was it an act of stupidity? Was it because of my bad luck? Or it 2015 is a year of bumps- as in baby bumps. Or my schedules are haphazardly bumping each other?

I took the hcg trigger shot today. Today is Tuesday. 7 days to go before embryo transfer. I feel so stressed. I just realized I need Ivig either on Wed, Thurs, or Friday. But, where is my beloved immunologist?

If I can't get an Ivig by tomorrow, then I need to have Ivig in HK on Friday. That means I need to fly to HK either Thursday afternoon or Friday morning. I am not enjoying my Amazing Race style of ivf.  His secretary said my appointment in on Saturday. Oh my god, I planned to travel on Sunday morning. I hope my consult will not end at 6:30 am Sunday. I am not exaggerating- it happened before. Worst of all his secretary said that I need to see my immunologist first before having my ivig. Ivig on Sunday morning and rush to the airport?

If I whole heartedly go to Hk for ivig on Friday, I cannot meet my immunologist on Saturday. I will just create some resentment here.

Well, I just hope 2015 is a year of baby bumps. Oops, it is not twins bumping each other ya!



Day 14 - preparing for FET

Today is day14. It seems my ovulation is a bit late. Anyway, I had my HCG trigger already. Estradiol 600, progesterone 0.45.  Urine LH negative. Shhh... I forgot to wait for the ivf doctor's comment. I just injected the trigger.

My inhibitions- Lymphocyte Immunization Therapy and Neupogen

It is a step by step process. First step, resistance. Why should i have LIT (Lymphocte immunization Therapy)? I believe I can get pregnant even without LIT. Second step, understanding. I try to understand how LIT works. I feel My grasp of understanding is less than 40%. Nevertheless, I tried.  Third step, acceptance.

If LIT is banned in America, why should I try it? If it is banned, I will think of two sides. One, it is unproven. To protect the safety of the public, the government needs to ban it. Second, it is banned because it is lobbied by pharmaceuticals? Ivig is also a blood product marketed by the giant pharmaceuticals. They are competing profitability with several thousands of unknown doctors.

Maybe I am brain washed but I voluntarily wanted to have LIT. Is it because my stubborn fairy godmother also changed her stand? My fairy godmother does not believe in immunology as a factor of infertility. After series of debate, she asked me to have LIT. She said it is to increase the chance of pregnancy. Case closed! I believe in immunology as a factor for my infertility. I had LIT done. I said in the past that I will wait for miscarriage to happen first before believing in immunology.
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How about Neuopogen? First step, resistance. Second step, resistance. Third step is also a resistance I guess. I try to understand but the comprehension is still vague for now. Neupogen involves stimulating the bone marrow to produce more white blood cell. Bone aches, ouch, ouch and what is the benefit? If I have plenty of white blood cells that means I have magnified my nk cell? I will be more resistant to infection, more nk cells to kill the embryo? Uhum... Wrong... We want Neupogen because it can stimulate the tropoblast growth factor. I just emailed my hematologist in HK. He confirmed gcsf receptor is found in cancer cells of leukemia. It is safe to me even if I have family history of cancer. Why? Because my tnf-alpha is high or because I don't have cancer yet for now?

With LIT, I have heard of several success stories within my circle of friends. With Neupogen, it seems that drug is new or not yet available in our market. Where can I find success stories. Do we have Neupogen teens already? Its safety on the fetus is already established? Maybe I am not yet prepared. I dont feel the benefit outweighs the risk. According to my ivf doctor, they use Neupogen on patients that experience implantation failure even with ivig and lit. I am not cursing myself. I wait for implantation failure to happen first before deciding to believe in gscf. Can neupogen cause leukemia in fetus?