These questions popped up the yesterday while I was doing my lymphocyte immunization therapy:
1. People with latent tuberculosis may get positive in the skin tuberculin test. What is responsible for the skin sensitivity test? We are expecting for a delayed type hypersentivity reaction, correct? So, are we checking for its T-cell? Hmmm... T-cell is a white blood cell.
2. What if the donor has latent tuberculosis, can pulmonary tuberculosis spread through blood transfusion? I believe Philippines belongs to the top 10 countries with the most incidence of tuberculosis cases. But my doctor assured me tuberculosis bacteria cannot be spread thru blood transfusion.
3. What if my donor had undetected autoimmune disorder? I have read some articles say having HLA-B27 gene does not necessarily mean that you will get spondyloarthropy. Why is it so? I guess because there is no HLA-B27 antibody to react with the surface antigen of the host cell. Therefore no inflammation. What if the donor has undetected rheumatoid arthritis? This entails I will produce HLA-DR4 antibody. Do I know my genome sequence? If I dont have HLA-DR4 gene, it will not affect me. What if i have that gene, then it will trigger my autoimmunoty. Correct?
4. Prions are not also included in the blood screen.
5. Are there other infections that can be spread thru blood transfusion? I am referring to mycoplasma and other curable bacteria infection that is not included in the standard blood screening test.
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