Wednesday, August 13, 2014

Immune tolerance- puzzled

Doctor said i have developed tolerance against my husband's lymphocyte. His conclusion was based on my induration size comparison.

How did my doctor program the immunologic tolerance? Is it by coincidence? Did my immune system become unresponsive to my husband's lymphocyte? Is this immune dysfunction, immune suppression or immune tolerance? If I had developed immune tolerance, then on my second LIT I should react to my husband's lymphocyte? Should I or should I not develop pustules from 'new' donor lymphocyte? What is the mechanism behind immune tolerance?

What is the definition of immune tolerance? Does immune tolerance mean immune suppresion? If I was exposed to tuberculosis bacteria for 6 months, my immune system will be programmed to tag tuberculosis bacteria as 'self' and will allow it to proliferate? Immune tolerance is scary in my crazy perspective. Btw, how does my immune system differentiate bacteria from foreign lymphocyte? What cells will attack bacteria? What cell will attack foreign lymphocytes? And most importantly, what cells will attack the fetus? Is mechanism behind foreign lymphocyte tolerance the same as the mechanism behind bacteria tolerance?

What is autoimmune disorder? My understanding about my autoimmune disorder is my T cells mistakenly tagged my eyes as 'foreign', then it attacked my eyes causing my eyes to get inflammed. I need immune tolerance so that my immune system will not attack my eyes.

Is autoimmune disease the cause of my infertility? Will I be at higher pregnancy risk compared to his other patients? I remember on my initial consultation with my immunologist he has mentioned  Th1, Th2 and T reg. T regulatory cell is the police or immune supressor... Will check immunotherapy and T reg on my free time. How does lymphocyte immunization therapy work? Does LIT increases the T reg cells? I guess T reg cell and anti-idiotypic antibody are two difference entities.

Regulatory T cell and immune tolerance

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