Tuesday, August 19, 2014

Questions on idiotypic and anti-idiotypic antibody

I am stucked with my own reasoning glitch. I said in the past:  If I don't develop anti-blocking antibody against my husband , it does not necessarily mean  that I may not produce anti- blocking antibody against my husband in the future. Applying my logic, if I don't develop  anti-blocking antibody against my fetus in the first trimester, it is not guaranteed that i will not develop anti-blocking antibody against my fetus in my second trimester of pregnancy.

What is the anti-idiotypic antibody for? I guess this is a principle of double negation: -1x-1=+1. Double negation cancels the effect of negation. I guess anti-idiotypic antibody (anti-anti-HLA antibody) mimics those of my husband's HLA? Does anti-idiotypic antibody trigger the production of idiotypic antibody? Who knows, it is a cyclic and reversible process. How does anti-idiotypic antibody suppress immune response? I guess anti-idiotypic antibody mimics that of my husband's HLA. And I guess it will compete with my fetus HLA antigen in binding with anti-HLA antibody.

Can we do some immunologic engineering here? What if we intentionally select those with autoimmune disorder as donors? Then inject their lymphocyte NOT on me (on other patients please....). Their immune system will create anti HLA-B27 antibody and then it will trigger the production of secondary antibody which is the anti anti-HLA-B27 antibody. Then collect the anti anti-HLA-B27 antibody and sell it as vaccine.  Perhaps not for fertility treatment but this will be a breakthrough cure for spondyloarthropathy and uveitis. Anti Anti-HLA-DR4-antibody,  anti anti-cancer protein-antibody. Isn't it great? I will be the future Nobel Prize awardee in immunology. Ehem...

I am not against my immunologist. ^.^ I am just inquisitive. I don't believe much on the PRA thing. But I believe in him. Cyclic reasoning ya! Whatever.

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