Finally, I found a new recruit willing to join my anti Neupogen camp. We will invite you to our inaguration soon.
Wow! I told him GCSF- receptor is found in trophoblast cells. I also told him that my hematologist advised me to use GCSF to stimulate the growth of my trophoblast. And I handed him a print out of my Neupogen inquiry. He then asked whether I took Neupogen or not? He silently stared at me as he waited for my answer. I said no! I did not. But I should take 300 micrograms three times prior to/ after the embryo transfer.
By the way, the print out says: Yes, gcsf receptor is found in cancer cells participularly in leukemia. Even if I have family history of cancer- that drug is safe on me.
He then asked why I don't like to take Neupogen. It appears to me that the hematologist just labelled me as a safe patient without even bothering to know the type of cancer runs in our family. What if the cancer history that I was referring to is leukemia? I may have a mutated gene responsible for leukemia. The mutated receptor may cause cancer.
Then, he told me don't take that drug. Bad Sheila played a devil's advocate again! I told him GCSF is an immune modulator. He said he knows that. There is also GCSF receptors in the immune cells. This can also cause negative reaction towards GCSF.
He needs more clinical data. So, do I. I am not volunteering to be a guinea pig yet. Now, I rest my case. I finally succeeded to recruit one LOYAL member to my camp!
Oops, He said RICA is the first clinic that was accredited by Dr. Alan Beer in Asia. Who the heck is RICA? Wahaha... I just notice the Rica he was saying is his clinic. Reproductive Immunology Center Asia!
Oops, I also saw in the web that gcsf receptors are also found in non hematopoietic malignant cells.
http://www.nejm.org/doi/full/10.1056/NEJM199012133232418
http://onlinelibrary.wiley.com/doi/10.1002/cam4.239/full
Thursday, January 8, 2015
My Viagra blooper
My IQ is less than 100%. Oh my god, I took it orally. Whose fault is it? My fault or my doctor's fault? He did not even write Viagra pessary in the prescription. he said there is no such thing as viagra pessary in the market. There is only one standard form of viagra. Hehe, perhaps I was sleepy again during the consult.
I forgot how did he discover that I took Viagra orally. Ah, he asked enumerate all the side effects from Viagra and ivig. Maybe I enumerated too much. Blurred vision, palpitation etc... Good detective!
I forgot how did he discover that I took Viagra orally. Ah, he asked enumerate all the side effects from Viagra and ivig. Maybe I enumerated too much. Blurred vision, palpitation etc... Good detective!
Tuesday, January 6, 2015
Anyone interested to bet on my FET outcome?
Minimum bet $50. Betting start now, closing 7am Jan 13 (before the embryo transfer). Honestly, the patient is unwilling to bet her hard earned 50 dollars on herself.
Pro:
- outstanding quality embryo (It is the embryo of the year for that ivf center. I felt like my embryos have won the 'embryo pagent'. This is true or just a consolatory remarks, I take their word for it.)
- body mass index 21.3
- lining 0.97 mm, follicle 19.3 mm a day before the HCG trigger. (Good lining)
- progesterone before the trigger 0.45; estradiol 600
- endometrial receptivity: 16 points- 60%; with heparin it may reach to 17 point or perhaps 19 points which translates to 77% chance of conception.
Con:
- immunologic failure: cat1,2,4,5
- ankylosing spondylitis and uveitis ( autoimmune disorder)
These are my concerns:
- 20 eggs retrieved; 12 fertilized; 9 survived til day 3; 5 survived til day 5. How many will survive the freezing? It seems like my embryo had sluggish growth. But 5 had made it. My immunologist remarks keep on reverberating in my mind. Once upon a time, he told me if I won't correct my immune problem. My eggs will be surrounded by tnf-a. At the time of harvest, they may look perfect. However, the embryos will have sluggish growth. I had ivig on day 1 of the stimulation cycle. His tnf-a theory maybe a scary truth.
- my husband's chromosome problem?
- my age? I am 38 yrs old already.
- cant understand why my embryo developed is just 25~35%. (Is it 5 or 7 embryo? )
Medications:
- ivig before embryo transfer
- prednisolone
- clexane
------
- neupogen? Yes or no? Grrr...
I feel stressful and pessimistic because I am resisting the Neupogen. Relax, just believe in what I believe!
Pro:
- outstanding quality embryo (It is the embryo of the year for that ivf center. I felt like my embryos have won the 'embryo pagent'. This is true or just a consolatory remarks, I take their word for it.)
- body mass index 21.3
- lining 0.97 mm, follicle 19.3 mm a day before the HCG trigger. (Good lining)
- progesterone before the trigger 0.45; estradiol 600
- endometrial receptivity: 16 points- 60%; with heparin it may reach to 17 point or perhaps 19 points which translates to 77% chance of conception.
Con:
- immunologic failure: cat1,2,4,5
- ankylosing spondylitis and uveitis ( autoimmune disorder)
These are my concerns:
- 20 eggs retrieved; 12 fertilized; 9 survived til day 3; 5 survived til day 5. How many will survive the freezing? It seems like my embryo had sluggish growth. But 5 had made it. My immunologist remarks keep on reverberating in my mind. Once upon a time, he told me if I won't correct my immune problem. My eggs will be surrounded by tnf-a. At the time of harvest, they may look perfect. However, the embryos will have sluggish growth. I had ivig on day 1 of the stimulation cycle. His tnf-a theory maybe a scary truth.
- my husband's chromosome problem?
- my age? I am 38 yrs old already.
- cant understand why my embryo developed is just 25~35%. (Is it 5 or 7 embryo? )
Medications:
- ivig before embryo transfer
- prednisolone
- clexane
------
- neupogen? Yes or no? Grrr...
I feel stressful and pessimistic because I am resisting the Neupogen. Relax, just believe in what I believe!
The omnipotent Neupogen
http://www.jimmunol.org/content/168/4/2011.full.pdf
http://www.bloodjournal.org/content/bloodjournal/102/2/734.full.pdf?sso-checked=1
https://kops.uni-konstanz.de/bitstream/handle/123456789/7891/Aulock.pdf?sequence=1&isAllowed=y
Should I reject or accept Neupogen? It is an immune modulator. It suppress Tnf-a and other interleukins. It has anti-inflammatory effect. Good for arthritis as well. Neupogen can be used to fight off infection as well. Cancer patients use this drug to stimulate neutrophils to fight of infection. It can be useful to patients fighting graft versus host disease, and many more. It sounds like gcsf is a wonder drug. I just wonder why it was not used on Ebola patients?
Neupogen is also a trophoblast growth factor. It is used for patients who failed implantation with ivig and Lit.
Anyone still joining my anti-neupogen camp? Neupogen cost a fraction of ivf only. It is cheaper than Ivig. To me, It is like buying an assurance. For the meantine, I cannot accept the terms and conditions of that assurance. I don't feel its benefits outweighs the risk yet. No, for now!
In the future when I am in desperate mode, I may sign and accept the terms and conditions even without reading them. I just hope I am not yet menopausal be then.
http://www.bloodjournal.org/content/bloodjournal/102/2/734.full.pdf?sso-checked=1
https://kops.uni-konstanz.de/bitstream/handle/123456789/7891/Aulock.pdf?sequence=1&isAllowed=y
Should I reject or accept Neupogen? It is an immune modulator. It suppress Tnf-a and other interleukins. It has anti-inflammatory effect. Good for arthritis as well. Neupogen can be used to fight off infection as well. Cancer patients use this drug to stimulate neutrophils to fight of infection. It can be useful to patients fighting graft versus host disease, and many more. It sounds like gcsf is a wonder drug. I just wonder why it was not used on Ebola patients?
Neupogen is also a trophoblast growth factor. It is used for patients who failed implantation with ivig and Lit.
Anyone still joining my anti-neupogen camp? Neupogen cost a fraction of ivf only. It is cheaper than Ivig. To me, It is like buying an assurance. For the meantine, I cannot accept the terms and conditions of that assurance. I don't feel its benefits outweighs the risk yet. No, for now!
In the future when I am in desperate mode, I may sign and accept the terms and conditions even without reading them. I just hope I am not yet menopausal be then.
Welcome 2015- my bumpy year?
I bumped my car today. Was it an act of stupidity? Was it because of my bad luck? Or it 2015 is a year of bumps- as in baby bumps. Or my schedules are haphazardly bumping each other?
I took the hcg trigger shot today. Today is Tuesday. 7 days to go before embryo transfer. I feel so stressed. I just realized I need Ivig either on Wed, Thurs, or Friday. But, where is my beloved immunologist?
If I can't get an Ivig by tomorrow, then I need to have Ivig in HK on Friday. That means I need to fly to HK either Thursday afternoon or Friday morning. I am not enjoying my Amazing Race style of ivf. His secretary said my appointment in on Saturday. Oh my god, I planned to travel on Sunday morning. I hope my consult will not end at 6:30 am Sunday. I am not exaggerating- it happened before. Worst of all his secretary said that I need to see my immunologist first before having my ivig. Ivig on Sunday morning and rush to the airport?
If I whole heartedly go to Hk for ivig on Friday, I cannot meet my immunologist on Saturday. I will just create some resentment here.
Well, I just hope 2015 is a year of baby bumps. Oops, it is not twins bumping each other ya!
I took the hcg trigger shot today. Today is Tuesday. 7 days to go before embryo transfer. I feel so stressed. I just realized I need Ivig either on Wed, Thurs, or Friday. But, where is my beloved immunologist?
If I can't get an Ivig by tomorrow, then I need to have Ivig in HK on Friday. That means I need to fly to HK either Thursday afternoon or Friday morning. I am not enjoying my Amazing Race style of ivf. His secretary said my appointment in on Saturday. Oh my god, I planned to travel on Sunday morning. I hope my consult will not end at 6:30 am Sunday. I am not exaggerating- it happened before. Worst of all his secretary said that I need to see my immunologist first before having my ivig. Ivig on Sunday morning and rush to the airport?
If I whole heartedly go to Hk for ivig on Friday, I cannot meet my immunologist on Saturday. I will just create some resentment here.
Well, I just hope 2015 is a year of baby bumps. Oops, it is not twins bumping each other ya!
Day 14 - preparing for FET
Today is day14. It seems my ovulation is a bit late. Anyway, I had my HCG trigger already. Estradiol 600, progesterone 0.45. Urine LH negative. Shhh... I forgot to wait for the ivf doctor's comment. I just injected the trigger.
My inhibitions- Lymphocyte Immunization Therapy and Neupogen
It is a step by step process. First step, resistance. Why should i have LIT (Lymphocte immunization Therapy)? I believe I can get pregnant even without LIT. Second step, understanding. I try to understand how LIT works. I feel My grasp of understanding is less than 40%. Nevertheless, I tried. Third step, acceptance.
If LIT is banned in America, why should I try it? If it is banned, I will think of two sides. One, it is unproven. To protect the safety of the public, the government needs to ban it. Second, it is banned because it is lobbied by pharmaceuticals? Ivig is also a blood product marketed by the giant pharmaceuticals. They are competing profitability with several thousands of unknown doctors.
Maybe I am brain washed but I voluntarily wanted to have LIT. Is it because my stubborn fairy godmother also changed her stand? My fairy godmother does not believe in immunology as a factor of infertility. After series of debate, she asked me to have LIT. She said it is to increase the chance of pregnancy. Case closed! I believe in immunology as a factor for my infertility. I had LIT done. I said in the past that I will wait for miscarriage to happen first before believing in immunology.
---
How about Neuopogen? First step, resistance. Second step, resistance. Third step is also a resistance I guess. I try to understand but the comprehension is still vague for now. Neupogen involves stimulating the bone marrow to produce more white blood cell. Bone aches, ouch, ouch and what is the benefit? If I have plenty of white blood cells that means I have magnified my nk cell? I will be more resistant to infection, more nk cells to kill the embryo? Uhum... Wrong... We want Neupogen because it can stimulate the tropoblast growth factor. I just emailed my hematologist in HK. He confirmed gcsf receptor is found in cancer cells of leukemia. It is safe to me even if I have family history of cancer. Why? Because my tnf-alpha is high or because I don't have cancer yet for now?
With LIT, I have heard of several success stories within my circle of friends. With Neupogen, it seems that drug is new or not yet available in our market. Where can I find success stories. Do we have Neupogen teens already? Its safety on the fetus is already established? Maybe I am not yet prepared. I dont feel the benefit outweighs the risk. According to my ivf doctor, they use Neupogen on patients that experience implantation failure even with ivig and lit. I am not cursing myself. I wait for implantation failure to happen first before deciding to believe in gscf. Can neupogen cause leukemia in fetus?
If LIT is banned in America, why should I try it? If it is banned, I will think of two sides. One, it is unproven. To protect the safety of the public, the government needs to ban it. Second, it is banned because it is lobbied by pharmaceuticals? Ivig is also a blood product marketed by the giant pharmaceuticals. They are competing profitability with several thousands of unknown doctors.
Maybe I am brain washed but I voluntarily wanted to have LIT. Is it because my stubborn fairy godmother also changed her stand? My fairy godmother does not believe in immunology as a factor of infertility. After series of debate, she asked me to have LIT. She said it is to increase the chance of pregnancy. Case closed! I believe in immunology as a factor for my infertility. I had LIT done. I said in the past that I will wait for miscarriage to happen first before believing in immunology.
---
How about Neuopogen? First step, resistance. Second step, resistance. Third step is also a resistance I guess. I try to understand but the comprehension is still vague for now. Neupogen involves stimulating the bone marrow to produce more white blood cell. Bone aches, ouch, ouch and what is the benefit? If I have plenty of white blood cells that means I have magnified my nk cell? I will be more resistant to infection, more nk cells to kill the embryo? Uhum... Wrong... We want Neupogen because it can stimulate the tropoblast growth factor. I just emailed my hematologist in HK. He confirmed gcsf receptor is found in cancer cells of leukemia. It is safe to me even if I have family history of cancer. Why? Because my tnf-alpha is high or because I don't have cancer yet for now?
With LIT, I have heard of several success stories within my circle of friends. With Neupogen, it seems that drug is new or not yet available in our market. Where can I find success stories. Do we have Neupogen teens already? Its safety on the fetus is already established? Maybe I am not yet prepared. I dont feel the benefit outweighs the risk. According to my ivf doctor, they use Neupogen on patients that experience implantation failure even with ivig and lit. I am not cursing myself. I wait for implantation failure to happen first before deciding to believe in gscf. Can neupogen cause leukemia in fetus?
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